Some of the players in my group, who know me to be a fan of planar cosmologies like 2e/3.X/5e's Great Wheel and 4e's World Axis, have proposed that I run Planescape's Great Wheel with a twist.
There is no Prime Material Plane, and there never was. There are and were no mortals.
The elementals of the Inner Planes and the natives of the Transitive Planes become petitioners in the Outer Planes upon death, who then become outsiders. When an outsider dies, nobody knows what really happens; some say the outsider merges with their plane, others claim that the outsider reincarnates, more still posit that the outsider ascends to a higher reality, and a pessimistic few point to oblivion.
Could this kind of setting work without regular mortals and a regular Prime Material Plane? I imagine that the closest thing you could get to "regular people" and "regular worlds" are air elementals living in floating earth-motes in the Elemental Plane of Air, or perhaps vacuum quasielementals living on immense rocks in the Quasielemental Plane of Vacuum.
I have run settings wherein nobody needs to eat or drink before, so partial post-scarcity is something I know how to handle.
If you think about it, this might not be so bad an analogue for a generic fantasy world. The Elemental Plane of Water takes the place of the ocean, the Paraelemental Plane of Air is the equivalent of the frozen north, the Elemental Plane of Earth is similar enough to the Underdark, the Positive Energy Plane under a more Feywild-like lens could make for lush jungles and verdant forests, the Quasielemental Planes of Ash and Dust would make for exotic deserts, and so on.
The only thing that is missing is a spot for a generic "plains and grasslands" area apart from the Outer Planes, and the Quasielemental Plane of Mineral already exists between Earth and Positive Energy.
Certainly, other settings, like Exalted, already do something similar.
Does anyone have any ideas on this?