How do you do them right while still keeping it reasonably serious (as in not an edgefest or a comedy)?
What kinds of plots or concepts would be good for one?
>>55272179
If you've not watched Assault on Arkham, do that.
Capeshit focusing on bad-guys should really show off the kind of skullduggery and scheming that supervillains are good at, expect put to good use.
I assume you want villains?
If so then I would run it like a Sinister-Six or Flashe's Rogue's plot.
Theirs some Big Good Guy who none of the characters ever seem to beat so they decide to team up, and make some big plot to beat them. Have them all be B & C-list villains against an A-tier. They can fight other B&C heroes and villains as they prepare their big attack on the main Hero.
>>55272340
But personally, I think a group fo Evil-Heroes would be more interesting.
Imagine a team of superpowered people that do good things for all the wrong reasons. Some are sadistic blood knights who realized they can kill criminals and no one really care, their glory hounds who are only their to save you when the camera's rolling, or their greedy bastards just there for the product placement opportunities.
Run them like actual criminals. Villainy isn't all about punching Wonderboy in the face.
Have fights against other villain groups. Attacking military bases to grab a secret weapon. Terrorizing the populace to build hype for your team so you can attract mooks and potential new members.