What are some ideas for campaign stories for 5e? When I DM I

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What are some ideas for campaign stories for 5e?

When I DM I usually focus on some world ending event that, if the players fail, will doom everyone. For example, some dragon priest is gaining power to raise an undead army of dragons to kill all of man, a rift to hell opened up releasing demons and vile creatures and the players have to close the rift, a great wizard is trying to master an ancient black scorcery that can control the mind so other so he can enslave the entire world, etc...

What are some good ideas that still have that epic important feeling to them, but don't feel so generic? It seems so cliche to use "chosen ones" and "prophecy" type settings.

Any ideas to help me out? I want something a bit more realistic sounding. Themes like war, rebellion, a plague, radical zealots, betrayal, etc...

I kinda want my campaign to have a game of thrones/ renaissance feeling to it as in betrayal and lies are everywhere.

Any suggestions?