Is it possible to genetic modify humans to let them live longer?

too early to tell

>>8463607

Definitely. We're nowhere near being able to do it, tho.

>>8463658
Is the problem the actually therapy or delivery?

These days all you hear about is crazy crap they can do with CRISPR, not how they'll actually apply it to humans.

Do we even have a firm grasp of what causes aging? I thought all we have are a bunch of conflicting theories.

>>8464086
Telomerase shortening

>>8464701
how can someone not know this, have you even had biology

>>8464028
More ethics and our own lack of understanding of the human genome. We may have sequenced it but it's equivalent to transcribing an entire book written in a foreign language that has no speakers or native readers. Then multiply that difficulty by a thousand because genes can be read in all sorts of crazy ways.

>>8464753
Nope never studied bio

>>8464701
I talked to a molecular biologist this summer and he said that telomerase shortening is merely a sign of aging and not what causes aging...

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Yes lad, it's possible to extend human lifespans. Prepare your anus for SENS

>>8464774
When they are shortened enough, the cell cannot divide any further

China has pretty much already done it

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put aglets on your telomeres and you'll get the Nobel Prize

>>8464701
I heard people with a lot of moles tend to live longer due to this telomerase thing

>>8464933
my cats will just chew them off like they do my aglets.

>>8464701
there's no proof of causation, only correlation.

i think a combination of environmental changes and genetic modification will lengthen human life. the real goal is ending senescence.

>>8463658
This
Inb4 muh crispr muh telomerase

>>8464774
this is heavily debated

>>8465039
>what are melanomas

>>8464775
How the fuck does he look so young?

>>8464756
So then in situations where there's only like one gene you need to change, they won't do it because they don't know how it will effect the rest of the system?

>>8464784
My understanding is that the cell continues to divide, it just keeps on shortening the genome with every division so you lose genetic code.

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>>8463607
>Is it possible to genetic modify humans to let them live longer?

kys.

no

aging is related to reduction in telomeres allowing DNA to be damaged faster than normal bodily function can repair it leading to poor health/cancer/dementia

the DNA itself doesnt actually effect this

>>8463607
>humans to let them live longer
Why would you do such a monstrosity? Don't we have enough selfish self absorbed assholes? Do you hate that evolution is slowly happening in our species?

>>8463607
Sorta related question. If we manage to make and harness(meaning it doesnt genocide us or whatever) artificial superintelligence, wouldn't it be able to understand how DNA works pretty quickly?

>>8463658
>>8464028
Aging is a complex process with multiple symptoms that have multiple causes. For example, if you could extend the age of the body/cells, lewy body buildup in the brain would still be an issue, along with your aqueous humor in your eyes slowly turning solid.

As for editing the human genome... We simply don't have the knowledge. We would need a complete 'roadmap' of all human genes and know with absolute certainty what they all do and how they all interact. We are not even 1% of the way there.

>>8466905
first of all telomeres aren't a main driving factor of aging

secondly telomeres can be altered using gene modification

>>8463607
Us dieing is rooted in DNA. Telomeres put a limit on the number of times DNA can copy itself and when the telomeres unravel the cell that the DNA strand is in self destructs.

"During chromosome replication, the enzymes that duplicate DNA cannot continue their duplication all the way to the end of a chromosome, so in each duplication the end of the chromosome is shortened. The telomeres are disposable buffers at the ends of chromosomes which are truncated during cell division; their presence protects the genes before them on the chromosome from being truncated instead."

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Get a genetic sample of the patient when they are a baby. When the patient begins to age at 40, replace their DNA with the DNA they had as a baby, thereby giving that person another 40 years of life.

This can be tested on short lived creatures like rabbits to get results fast.

What are some good reasons for humanity to fight off ageing and obtain a variation of biological immortality?

>>8467642
If you have to ask, you may as well kill yourself now.

>>8467642
What are some good reasons for humanity to fight off diseases and obtain various forms of medicine and vaccines?

so you dont die you stupid faggot

Not exactly related, but why aren't more countries jumping on the generic engineering train? I've read that only China and the USA have human trials planning to try and fight cancer with genetic engineering. Why?

>>8464775
When I'll get a job I'll make sure to donate to him desu
I like living too much to die

>>8467887
4 months ago he and SENS made progress in testing of proteins 6 and 11.

>>8467874
UK's too busy using genetic engineering to fight AIDS.

Plus did the CEO of some company manage to extend her Telomeres by like 20 years or something?

>>8467936
>UK's too busy using genetic engineering to fight AIDS.

I mean that's good in my opinion. More tests will lead to a greater understanding. It's just that you don't really hear about these tests. Maybe the public discussion is behind the topic?

Also, I've read about that CEO, and she is getting two gene therapies, I'll dig up a link when I get back home.

>>8467936
>did the CEO of some company manage to extend her Telomeres by like 20 years or something?
That's what she claims, but no independant party did the testing and we don't have any information about how they tested her

GM stock images are just the best.

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you guys notice how his beard is turning brown again?

>>8466961
this

imagine a plethora of 4chan imbeciles spouting the same "inb4 muh diz muh dat" excrement ad infinitum

just no

>>8468696
or edgy retards who are a bit too full of themselves

>>8466848
No, the cell undergoes senescence and stops replicating.

>>8464784
Yes but you can introduce telomerase and it will start again.

>>8465204
Moles are usually not melanomas though. And melanomas don't always form from moles

>>8467363
Explain immortal cancer cell lines. Checkmate fagget. You can also induce immortality in cell lineages.

>>8467936
CRISPR shits on HIV, it'll be cured in the next decade depending on how long it takes for it to pass tests.

>>8469032
Isn't the problem with CRISPR still delivery.

>>8463607
Probably; there's probably another way to do it though. And not just one.

>>8469543
Not particularly. It's very good at delivery, just sometimes delivers to the wrong place.

The risk of cancer from this is very very low, whereas the risk of keeping HIV once you have it is basically 100%

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>CRISPR
Herro guys. I woulda rike to talk to yous about NgAgo. Twust me the scientist. It is CRISPR killer.

>>8470638
I mean isn't the problem for in vivo CRISPR that you still need a vector that delivers the cas9 to the appropriate cells?

>>8470711
And fuck this guy, not even the Chinese like him.

>>8466961
You're right. We should stop making medical advances because sometimes it'll make a bad person live longer.

Let's also stop making everything about life easier, because people today just have it too easy and they become worse because of it.

Fuck all technology let's live in caves

So how much money will it cost the average joe to get life extension services when it comes out in 20-50 years?

>>8463607
Probally, but is it morally right?

We only live our lives so intensely because we know that some day the world around us will cease to exist.

>Would you want to live a boring life?

Do cancer cells age?

>>8472210
You can't really live a boring life.

There is always things to do. You only become bored when you become a lazy sack of shit who doesn't want to do anything.

>>8472235
I'm pretty sure that some don't. Look up Henrietta Lacks

>>8471566
no reason why it would be expensive

>>8472235
Some are immortal. However they undergo significant genotypic and phenotypic drift. A lot of the immortalized cell lines used by scientists have aberrant number of chromosomes or deformed chromosomes.

>>8472210
I think boredom is a small price to pay compared to the void that is death. Pretry sure I would have plenty of shit to do anyway, and I would probably enjoy my life even more since I would not have to rush everything.

>>8463607
yea, start by cutting out the 7 bottles of Mountain Dew a day from your diet and you'll live a lot longer

>>8473905
You can also do a lot more things and master new things.

>>8472210
That's not true. I live my life intensely because it feels awesome to do cool shit.

I think there are also a lot of people who say "Ah fuck it what can I do anyway" too and end up working in a toll booth and watch netflix all night.

I've heard it said fatalism is a lot more common with poorer folks, do you think that's true? If so what would you make of giving them the hope that they might one day live in a Not Shitty Place/Time?

Recently I've seen a rise in these threads talking about life extension, biological immortality, editing human genes to extend one's life and such? Is this a new fad or is such things possible in this century.

>>8475320
such as

>>8475795
jeking off with the left hand

>>8470797
>I mean isn't the problem for in vivo CRISPR that you still need a vector that delivers the cas9 to the appropriate cells?
My lab uses third generation lentiviral vectors but we don't use CRISPR, not yet anyway.

>>8472235
>>8473754
You can still immortalise primary cells and make them cell lines without making them tumorigenic e.g. HEK239T cells, which are immortalised but not cancerous.

>>8475784
>Is this a new fad
Nope, gene therapy has been around for decades but it is slowly gaining more momentum.
>or is such things possible in this century.
ehhh, i dunno, a long way to go

simple monogeneic diseases could be cured by this century, aging, probably not. Probably has a lot of ethical shit behind it.

>>8463607

Yes and no.

Some genes become "problematic" later in life, but you would have to modify them in a very specific and complicated way, which would require decades, constant flow of money and trial and error.

If someone is willing to do it, he will have to accept that the results will be around when the sons of his son's son are alive.

>>8475815
Getting rid of aging this century would be one of the greatest things mankind could ever do.

>>8475813
I know, I work with Her 293s. But
1) hek 293s are embryonic and thus have different properties from adult cells
2) hek 293s and all other immortalized cel lines still undergo severe genetic drift like I mentioned earlier meaning they would probably cause problems in a live organism

>>8464775
Didn't him and SENS make progress in their 7 step plan awhile back, and then did a Q&A about it?