CRISPR Thread

Off target effects is basically what called for the moratorium. The Chinese team was over-eager and rushed to embryo modification on a technology that was super inaccurate.

We still really haven't solved this inaccuracy problem so chill.

Also there is hella redundancy in biological systems so a simples control x + control v might not work here.

SUPERHUMAN WHEN?

what field can do this?

i want to breed humans have optimal traits for all kinds of sports, train them and have them win everything and bring my country and "coaching" to glory.

>ideal leg length + all high power fast twitch fibers + injury resistance + psychological genes to make them love to train and recover well= amazing sprinters
>breed man to have short arms and femurs, high test, high gH (huge joints), lots of fast twitch muscles, he'll set world records in powerlifting

IT GOES ON AND ON

>>8003798
>until the full implications
What the fuck does that even mean? It really sounds like a "I better cover my ass here" kind of statement.

>>8003798
We're fucked. If one virus or form of cancer manages to latch onto one of the specific modified genes (as in only affect that gene), then it will fuck genetically modified humans with those specific genes, especially if it's already a resistant strain.

>>8004001
It's a "let's not get right to modifying humans before we decide what is immoral" statement

>>8004001

it means, we want to do this but are scared people will call us nazis so let's hang back

the idea of rich billionaires paying for this technology and it going wrong and them gradually becoming mutated like the guy from the end of Robocop and trying to cover it up is super fucking brutal

I need to watch that scene from Blade Runner again when Tyrell is talking about how hard synthetic life is to engineer

Same shit as when RNAi exploded. Like another anon already said, off-targets are a huge problem. I wouldn't be too optimistic about this.

>>8003798
Assuming it becomes free and legal for everyone to research, we may start seeing non-abominations start happening in about 100-200 years. Along the way thousands will die or be born with little to no noticeable benefit, if they are able to be born at all.

You really shouldn't be afraid of this, not yet at least. The technology is still in its infancy.

>>8004023
>immoral
This is just opening a whole new can of worms, what [math] is [/math] moral?

>>8004083
More like 100 or 200 billion years

>>8004213
Here is your (you)

>>8004064
they're actually not, one of the labs next to mine has deep-sequenced some lines they've stably transformed with CRISPR constructs and they found basically no evidence for off-target effects

i mean yeah, it depends on careful guide design, but it's definitely possible to do CRISPR editing in a specific way

>>8003995
Why don't they just selectively breed people in test-tubes and call them: 'Children of the State' or something

>>8003798

Is shit like this only for embryos or can it be used on real people too?

>>8004525
There's been some success using it to modify specific tissues in adult organisms, but in general it's extremely limited because it has to successfully modify many, many cells in your body instead of only one or two in a zygote. (The case in question was one where the diseased cells were dying and the modified cells successfully replicated, so the tissue easily became largely modified cells.)