http://www.history.com/news/history-lists/7-unusual-experiments-by-the-u-s-military
The Edgewood Arsenal Drug:
>More than 5,000 soldiers served as guinea pigs for the project, which was intended to identify non-lethal incapacitating agents for use in combat and interrogations.
It's a constant social experiment that we pay for. Militias/National Guard are the way to go. States can determine who serves, regional coordination for nukes/ICBM would allow for various regions to pool resources and staff to run more complicated programs.