Does estrogen make cis men depressed?

>>8858392
No, trans meds have a side effect of depression for some people, trans or not.

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>>8858392
It's the opposite if we're talking about Estrogen only. Estrogen got antidepressive symptoms.

However if we're talking about the full hrt treatment, yeah, Anti Androgens can indulce depression (specially cyproterone acetate) and hormonal variations too.

>>8858392
Unclear. The most common hormonal issue is sex hormones that are too low. Fluctuating hormone levels also carry a higher risk of depression than stable cross-gender hormones.

Study-wise there seems to be some evidence that men react poorly to high estrogen levels and women react poorly to high testosterone, separate from the body-changing effects, but nothing official, really.

>>8858392
I personally believe it'd depend on a lot of factors, like their personality and mental state. All healthy bodies should support both sex hormones, and if depression happens to a man on estrogen it's most likely because they don't like how they're affected by it.

>>8858392
From cancer studies there seems to be no indication that AAs, estrogen, or SERMs cause dysphoria or depression in cis men