Civilization was a mistake

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Have any non meme thinkers/writers tackled this in any substantial way?

There are obviously your anarcho-primitivist types but I find them to be absurd - bar total nuclear annihilation humanity is not going to revert back into hunter-gatherer tribes and seeing that the individual can not guarantee they'd even survive said apocalypse, planning or shilling for it is ridiculous.

What I'm more interested in is the fact that when one looks at the length of human history "civilization" is only but a small blip which leads me to wonder, seeing that we are nothing more than animals with the gift of higher intelligence maybe we are simply not biologically and/or psychologically cut out for the intensity and stress of the modern world.

I compare it to an animal raised in captivity: although they can be mentally functional they are more often than not prone to what can only be described as mental illness. This is not to say that their natural existence is necessarily better - only that after millions of years of evolution they are simply better equipped to deal with it psychologically.

I don't necessarily believe this but it does seem like an interesting train of thought I'd like to read about in full.