Let us break down this scene
As you can clearly see the Green Goblin is a metaphor of Donald Trump and his Muslim ban all across America but also particularly in New York.
When this character yells out "you mess with one of us you mess with all of us" well he's implying when he says "one of us" is singular but also plural. Someone cannot be simply "one" if they belong to "us". Because irregardless of someone's nationality, Heritage, ethnicity, sexuality, or religion, New York city has been a mixed bowl of cultures. People in their communities see muslamic folks in the everyday lives, it is normal. And to see a fellow New Yorker being attacked by the president and his administration is simply unjustly. So just like the protests on the Muslim ban happened throughout the night this scene takes place at night time. With New Yorkers fighting for their fellow man. Because that is the type of overarching culture that a Multicultural Society such as New York has brought up. Hence the quote "all of us".
Bravo raimi, mixing action adventure seamlessly with political commentary.
That was a lot of effort put in for a joke that wasn't funny. C-.