Polo thread, Kraken peasants not welcome

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Can someone help me figure out how the poloniex fees add up and end up affecting my trading?

I have a subhuman poverty peasant tier account, so the fees that apply to me are:

Fee: 0.15/0.25%

Now I don't completely understand... do they apply to both selling and buying? Sometimes sell/buy orders are split into several orders. Do the fees then apply to every order, or to the cumulative amount (or does it end up being the same? I'm no math wiz here).

And lastly, do the fees swallow a significant amount of profit if I trade too small of a price movement? Can it ever get to a point where a trade that is positive on paper, ends up being nonprofitable due to fees being larger than the price difference of my trade?

For example if I sell ETH at 0.02230, and later buy at 0.02183, that's a rather small price movement. Are the fees significant or can I yolo it up and consider them negligible?