How do I quit a job for a short term disability?

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I haven't been on here for a while but I remember it being a pretty decent place to ask for help.

I was recently diagnosed with a disability that gives me constant pain, nausea, shakiness, poor motor function, the whole nine yards. Imagine waking up every day with a hangover, that's essentially what it is. It's genetic, it's a known (but rare) condition, and I've been working very closely with a doctor who believes he has a treatment for me, should be good to go in about six months, after they take a bunch of precautions as there are some undesirable side effects. If I don't get the treatment, the general consensus is that my symptoms will get worse and worse until I die around age 45-55 (fortunately when you get the treatment your lifespan is normal).

I want to quit my job and experience life. I haven't had a vacation ever, I haven't seen my family since my graduation day from college (I'm 30 now). My girlfriend has been talking to me about wanting to do some kind of road trip, playing music on the street, being wild and carefree, and I know it'd be really irrational but at the same time I just want to be fun and carefree like I was when I was in school a decade ago, before I had this crazy health problem.

I feel like if I just put in my two weeks my boss would kill me, as I'm one of the anchors for the team. He gets real pissed when people quit, punching walls and throwing our equipment around and stuff. I like him as a person I don't want him to think I'm a coward, you get the idea.

In your opinion, what should I do? How do I quit? What kinds of plans should I have in place?