Should I stay or should I go?

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Anyone here with expat/relocation experience and especially making the decision?

I've moved to the UK for a job 5 years ago, and it looks like that a very real chance to hop to the US will present itself in the next year or so, which is something I always wanted to do. I've actually been to the place in the US I'd be moving to, and it's great (job, people, area) - so that's all good.

However I'd move even further away (10h flight instead of 2h) from family (and they are not happy about that prospect) and some close friends in mainland Europe. I've recently moved into a new place here as well, and for the first time in years, I'm actually quite happy where I am with my awesome housemate, despite the fact that the town itself is a bit of a craphole.

Wat do? I expect that I have to make a decision sooner than later, and I think I'm afraid that an opportunity like this won't come around (realistically speaking, chances are it will though).