Fuck Ryuko, marry Ryuko, kill everyone else.
Marry both Mako and Ryuko and get crazy on honeymoon
In that case, the only answer would be
>Fuck Satsuki so you can get them into 3-somes (really, it's all just a means for Satsuki and Ryuko to have happy sex together)
>Kill Nono so she's not messing up the sister in law x wife x you party.
Mako's got Gamagori, so they're fine left alone. Just give Gama a tap to let him know to take the genki for a ride so you can get some scissor sister time.
I wish you'd be erased from existence.
How to actually do it:
You don't have to do anything for Ryuko since she already has Senketsu who makes her happier than anything in the world anyway.
Marry Satsuki because knowing her sister won't be a spinster will probably be a load of her mind
Fuck Nonon because it'll chill her out and thus she can be befriended
Kill Junketsu duh
And Mako can be left alone since she has Gamagori.