Are there any anime with a main character who goes insane due to the lack of companionship?
>>165278
This has the feel you're probably looking for.
>>165281
NHK is probably your best bet.
>>165278
My life
Neon Genesis Evangelion.
if you want a somewhat positive ending go for NHK
if you want a never ending cycle of loneliness, complexes, sexual confusion and existential crisis mixed with a clusterfuck of kabballistic thought and surrealism go with Evangelion