I am looking to run a Campaign set in the mid 19th century wherein

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I am looking to run a Campaign set in the mid 19th century wherein the players are exceptional Gentlemen (or ladies should a player desire to play a women) who are tasked with transporting an artifact across the world while being hunted, I want the main fixture of the game to be in the firearms of the 1840's and narrative focused on how the players secure transportation while evading the groups intent on securing the artifact for themselves. Are there any systems that can do this well? I won't be needing any system for magic as the players won't have access to it in any meaningful way.