Question: Say we send a probe/ship into space with the intention

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Question: Say we send a probe/ship into space with the intention of scanning neighboring solar systems, the materials in them, materials in the asteroids, gather materials from asteroids, gather dust in nebula clouds and space dust to study, and sending rovers down to planets in the solar systems to analyze the planets. What are some things that would cause this mission to come to a halt and send the probe/ship back to earth?

I'm working on a small game that was originally intended to be a scifi combination of eve online, mass effect, and minecraft in the form of ship exploration, but I've decided I want to make this a more realistic futuristic ship/probe simulation where the intention is to do all the things I refereed to early before you need to end your mission. I want this to be a fun and interesting game that sparks the interest of science and analyzing new things for kids or just be a fun fascinating thing for teens and adults to play.