Would it theoretically be possible to cure all autoimmune diseases by injecting patients with monoclonal antibodies specifically targeting memory B and T cells? Wouldn't that make it possible to reset their acquired immunity back to how it was when they were born after only a few doses? That ought to make the patient's immune system permanently forget how to attack friendly tissues.
pls respond
>>9058661
Cells die.
The ones doing the damage have memory in their DNA, thus, when new ones are created they have a copy of that DNA. If you inject those cells they would die eventually and new ones (with the old memory) would replace them.
I could think of inhibiting immune cell production and providing different ones like you say through some kind of dialisis. Would be hard and expensive and probably wouldn't work. If it works it would be a treatment not a cure, much like current solutions for autoimmune diseases. Bone marrow, thyme, spleen, etc. transplant could somehow work theoretically.
A cure would consist on some kind of dna modification, which I think is ridiculous for our time.
>>9058916
Rituximab is a lymphoma drug made from a synthetic antibody that kills B cells. Why couldn't you make another injectable antibody targeting antigens on memory B and T cells? You're right that they store the acquired immunity information in their cell line's DNA, but if you could kill all of them at once, couldn't you regenerate new naive ones from your bone marrow that don't have the acquired DNA to produce autoantibodies?
>>9058661
The cure to autoimmune disease is to go outside, pick up a spoonful of dirt from the garden, and eat it.