is there anyway to manually alter a human's reward pathway

Knock-out edit the gene that codes MAO-B enzyme.

>>8303527

Listen to music.

>>8303527

>without the use of illicit drug

That's retarded. Psychoactive drugs are exactly what you'd use to alter your brain chemistry. Your question is like asking how to open the locked door to your house without using the key you have in your hand. Also:

>every 5mins

You would just get used to it very quickly and then you'd feel the same as you did before starting this process.

File: brain.png (384KB, 1366x808px) Image search: [Google]

384KB, 1366x808px

>>8303527
Complete lack of understanding of how neuroscience works. Top kek

>>8303562
I have been on Ritalin 10mg per day for a few months and I don't feel like I've been growing a tolerance. It is still just as therapeutic but the feeling isn't as novel. Am I just lucky or does this come from using the drug responsibly/as directed?

>>8303579

>once per day
>every 5 minutes

Why do you think these two things are anywhere close to the same?

>>8303579
>>8303612

I mean, just do the math. 24 hours in a day is 1440 minutes in a day is 288 5 minute intervals in a day. You're asking why taking a drug 288 times a day is unsustainable while taking a drug 1 time a day isn't.

>If 288 teaspoons of salt in one sitting will kill me, why can I eat 1 teaspoon of salt and not die?

That is what you're asking.

>>8303612
It isn't, I was more talking about the general mechanics of stimulants and dopamine sensitivity.

>>8303622
I mean the effects of the dopamine reuptake inhibition lasts around 4 hours, but yeah. I probably phrased it poorly, I was just asking about in general how tolerance works with stimulants.
>>8303626

>>8303622
>I mean, just do the meth

That's enough 4chan for me.