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Okay so ejaculation is caused by AFAIK release of epinephrin

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Okay so ejaculation is caused by AFAIK release of epinephrine/norepinephrine release, causing contraction of the smooth muscles in some part of your genitals.
Would it be possible to design a drug, that through alpha 1 reuptake inhibition (NERI) or maybe agonism, would cause immediate ejaculation upon administration (I think IV would be the most pharmacocinetically interesting RoA) ? It could have some medical (for exemple in sperm banks) and recreational uses, but I'm interested whether or not it could be weaponized as a non-lethal incapacitating agent, released just like tear gas or whatever for LE/riot control/etc uses.

I did some research :
>http://www.ncbi.nlm.nih.gov/pubmed/15674403
Methoxamine seems to have an effect, promoting correct ejaculation with few side-effects. Might a good lead, I think we should study this drug more in detail and maybe try to create some analogues that could be effective.
>http://www.ncbi.nlm.nih.gov/pubmed/15674403
A1 antagonists make you unable to contract your dick's smooth muscle enough to ejaculate.
>http://bjp.rcpsych.org/content/177/6/567.3
An NERI caused spontaneous ejaculation (SE). I think it proves that it could be possible to design a drug specifically with these properties, since it shows that drugs affecting NE can cause SE.
>http://www.ncbi.nlm.nih.gov/pubmed/19000555
An antipsychotic metabolizing to a NERI, also causes SE.
>http://www.lareb.nl/LarebCorporateWebsite/media/publicaties/2012_3_EJCP_ejaculation.pdf
Basically a literature review about cases of SE caused by NERI.
>http://parkinsonhope.org/rasagiline-induced-spontaneous-ejaculation/
MAO-B inhibitor causing spontaneous ejaculation. It might be a good idea to also study MAO-B inhibitors to create this drug, and maybe consider the drug having primarily MAO-B inhibition effects if NERIs fail to cause SE
What do you guys think ? Any suggestions ?
(sorry english is not my first language and I'm excited about this so I didn't take the time to check for errors)
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Get a life
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>>8081009
This is beyond briliant. A drug that literally makes you cum, the amount?of potential junkies this product could bring, the revenue, if only we could?make it so no does in fact ejaculate and incoprate that in the drug. Jesus Christ whoever could make this would be filthy rich.
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I think the opposite (a drug that can be taken at will to prevent you from ejaculating) would be more profitable.
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>>8081009
Start a crowdfunding project and become famous as crazy scientist.
You can escape the prison of normality
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>>8081148
>but I'm interested whether or not it could be weaponized as a non-lethal incapacitating agent, released just like tear gas or whatever for LE/riot control/etc uses.
not unless you also override the normal physiological refractory period
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>>8081009
>>http://www.ncbi.nlm.nih.gov/pubmed/15674403
>Methoxamine seems to have an effect, promoting correct ejaculation with few side-effects. Might a good lead, I think we should study this drug more in detail and maybe try to create some analogues that could be effective.
>>http://www.ncbi.nlm.nih.gov/pubmed/15674403
>A1 antagonists make you unable to contract your dick's smooth muscle enough to ejaculate.

You accidentally the second study.
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>>8081596
woop, wrong quoted post
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>>8081205
Why would you want this?

>>8081009
How would making your crowd ejaculate be a form of riot control? Honestly, that'd just make them riot harder.
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>>8081675
Seems like for a moment it would be effective and maybe have a psychological effect on them after as well. Still seems like tear gas would be a way more efficient go-to for riot police so not really helpful
>>
Stupid Speculation below

Is there a physical cause for arousal inside the genitals/prostate or whatever?

Like a "oh shit you are full of cum and need to dump this shit, get horny. type of response?

Could you install something that could trigger this and make someone horny at will
>>
Probably unrelated, but if it helps... I remember hearing about an OCD drug that has a weird side-effect. When some women who are taking it yawn, they instantly orgasm.
http://baillement.com/clomipramine.html

Good luck in your search, friend. You're doing important work.
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>>8081205

Yea, its called fucking Sertraline and Propranolol.

I took myself off it because I use to ejaculate easily within a minute, now it takes me about 20 - 30 minutes, sometimes not at all and I'm left feeling frustrated and sore.
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>>8081009
You could secretly administer the drug to your target, and show them some sort of disturbing or mundane imagery that they will associate with cumming themselves.

>release stuff in vents during a meeting or class
>everyone busts a nut over a powerpoint slide

Imagine the smell in that room as everyone looks around.
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>>8082657

/sci/ everybody
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Hi r/4chan
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>>8081714
I don't know, but apparently prostate massage works.
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>>8081205
amphetamines are already a thing
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>>8081675
Last longer in bed.

>>8082649
>>8082939
But they make it difficult to get a good boner. You'd want to keep a rock hard boner and not cum.
Thread posts: 19
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