You're just like me, aren't you? Why do you keep

>>37954917
to converse with like-minded failures

i think there's still hope for me, but it's so hard to find sometimes. i probably shouldn't keep coming here. also the new party rock pepe thing is really funny to me

>>37954917
im brown like you desu

>>37954931
Not everyone here is a failure? Or at least that's what I've experienced. This place is just fun to be in, to be honest.
>>37954991
I don't mind it, it's alright I guess. That meme. Keep strong to your clutch of hope.
>>37955009
Hmmm.

>>37955082
thanks anon. i'll try to hold strong

>>37954917
Why do you keep coming back here? Everybody here hates you. Fuck off. Attention seeking little cock goblin. saged

>>37955223
Oh, you're welcome.
>>37955346
It's fun and it was the first board I came across by chance. I don't seek out attention it just so happens others give it to me for whatever reason. I'd appreciate if you didn't call me those names.

>>37955402
Posts the same cartoon character over and over again.
>I don't seek out attention it just so happens others give it to me for whatever reason.

Just leave you tryhard little faggot. This place isn't for you.

>>37955493
I do no such thing? Why're you targeting me so maliciously? It's very off putting. I do belong here, like so many others have liked my presence clearly. Leave me alone please?

>>37955402
No one thinks what you do is charming here, go back to Tumblr.

>>37955542
Nah buddy. You can fuck right off. Go find a nice little discord, start some drama and milk that shit for attention then rinse and repeat. Don't thank me later, just gtfo already. sage

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Genetics[edit]
See also: Li

st of human leukocyte antigen alleles assoc

iated with cutaneous conditions
Around one-third of people with psoriasis report a family hist

ry of the disease, and researchers have identified gene

tic loci associated with the condition. Identical twin studies suggest a 70% chance of a t

win developin

g psoriasis if the other twin has the disorder. The risk is around 20% for nonidentical twins. These findings

suggest both a genetic susceptibility and an environmental response in developing psoriasis.[28]
Psoriasis has a strong hereditary component, and many gene

s are associate

d with it, but it is unclear how those genes work together. Most of the identifi

ed genes relate to the immune system, particularly the

major histocompatibility complex (MHC) and T cells. Genetic studies are valuable due to

their ability to i

dentify molecular mechanisms and pathways for further study and po

tential drug targets.[29]

Classic genome-wide linkage analysis has identified nine lo

ci on different chromosomes associated with psoriasis. They are called psoriasis su

sceptibility 1

through 9 (PSORS1 through PSORS9). Within those loci are genes on pathways that l

ead to inflammation. Certain variations (mutations) of

those genes are commonly found in psoriasis.[29] Genome-wide association

scans have identified other genes that are altered to chara

cteristic variants in psoriasis. Some of these genes express in

flammatory signal proteins, which affect cells in the immune system that are also involve

d in psoriasis.

Some of these genes are also involved in other autoimmune diseases.[29]

>>37955562
Oh my gosh, why does everyone think I'm from there? It's so ridiculous. I barely ever browse there.
>>37955643
I don't own a Discord and I don't want to? I don't want any drama, I'm not causing any at all, you are. I'm staying so.

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The major determinant is PSORS1, which probably a

ccounts for 35%-50% of psoriasis heritability.[3

0] It controls genes that affect the immune system or encode skin proteins that are overabun

dant with psoriasis. PSORS1 is located on chromosome

6 in the major histocompatibility complex (MHC), which controls important immune functions. Three genes in

the PSO

RS1 locus have a strong association with psoriasi

s vulgaris: HLA-C variant HLA-Cw6,[31] which encodes a MHC class I protein; CCHCR1, variant WWC,

which encodes a coiled protein that is overexpressed in psoriatic

epidermis; and CDSN, variant allele 5, which encodes corneodesmosin, a protein which is expressed i

n the granul

ar and cornified layers of the epidermis and upregulated in psoriasis.[29]

Two major immune system genes under investigation ar

e interleukin-12 subunit beta (IL12B) on chromosome 5q, which expresses interleukin-12B; and IL23R on chromosome 1p, which expre

sses the inte

rleukin-23 receptor, and is involved in T cell differentiation. Interleukin-

23 receptor

and IL12B have both been strongly linked with psoriasis.[31] T cells are involved in the inflamma

tory process that leads to psoriasis.[29] These genes are on the p
athway that upregulate tumor necrosis facto

r-_ and nu

clear factor _B, two genes involved in inflammati

on.[29]
Recently, the first gene directly linked to psoriasis has been identifie

d. A rare mut
ation in the gene encoding for the CARD14 protein

plus an environmental trigger was enough to caus

e plaque psoriasis (the most common form of psoriasis).[32][33]

Lifestyle[edit]

Lifestyle[edit]
Conditions r

eported as worsening the disease include chronic i

nfections, stress, and changes in season and climate.[31]

Others that might worsen the condition include hot water, scra

tching psor

iasis skin lesions, skin dryness, excessive alcoh

l consumption, cigarette smoking, and obesity.[31][34][35]

HIV[edit]
The rate of psoriasis in HIV-positive individuals is comparable

to that of HIV-negative individuals, howe

ver, psoriasis tends to be more severe in people infected with HIV.[36] A much higher rate of psoriatic arthritis occurs in HIV-positive individuals wit

h psoriasis than in those without the infection.[36] The immune response in thos

e infected with HIV is typically characterized by cellular signals from Th2 subset of CD4+ helper T cells,[37] wh

ereas the immune response in psoriasis vulgaris is char

acterized by a pattern of cellular signals typical of Th1 subset

of CD4+ helper T cells and Th17 helper

T cells.[38][39] It is hypothesized that the diminished C

D4+-T

cell presence causes an overactivation of CD8+-T cells

, which are responsible for the exacerbation of pso

riasis in HIV-positive people. Psoriasis in those with HIV/AID

S is often severe a

nd may be untreatable with conventional therapy.[40]

Microbes[edit]
Psoriasis ha

s been described as occurring after strep throat, and m


ay be worsened by skin or gut colonization with S

taphylococcus

aureus, Malassezia, and Candida albicans.[41]

>>37955672
why do you type like a faggot though? why do you end every sentence with a question mark? why do you say dump shit like waahh?

>>37954917
can i creampie you

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Mechanism[edit]
Psoriasis

is chara

cterized by an abnor

mally excessive

and rapid growth of the

epidermal layer of the skin.[44

] Abnormal production of skin cells (especially during wound rep

air)

and an overabundance of

skin cells result from the sequence of

pathological events in psoriasis.[17] Skin

cells are replaced every 3-5 days in psoriasis rather tha

n the usual 28-30 days.[45] These changes are believed to ste

m from the premature maturation of keratinocytes induced by an inflammatory cascade in the de

rmis involving dendritic cells, macrophages, and T cells (three subtyp

es of white blood cells).[11][36] These immune cells move from t

he dermis to the epidermis and secrete inflammatory chemical signals (cytokines) such a

s tumor necrosis factor-_, interleukin-1_, interleukin-6, interleukin-36 and i

nt

erleukin-22.[29][46] These secreted inflammatory signal

s are believed to s

timulate keratinocytes to proliferate.[29] One hypothesis is that psoriasis involves a defect

in regulatory T cells

, and in the regulatory cytokine interleukin-10.[29]

>>37954917
I hate that cartoon stop posting it.

>>37955725
I don't know what you mean by that question. Seems very hate filled if anything at all. I don't end every sentence with a question mark? Evidently not at least. I don't think I say anything dumb. Rarely if so. Maybe because of autocorrect or something.
>>37955748
That's not my concern? I can post what I want as long as it fits the guidelines. Sorry though, if that means anything to you.

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Psoriasis is classi

fied as a papulos

quamous disorder and is most commonly subdivided into diff

erent categories based on histological characte

ristics.[3][10] Variants

include plaque, pustular, guttate, and flexural psoriasi

s. Each form has a dedicated ICD-10 code.[53]

Psoriasis can also be classified into nonpustular and pustular types.[54]

Pathogenetic[edit]
Another classif

ication scheme considers genetic and demog

raphic factors. Type

1 has a positive family history, starts before the age of 40, and i

associated with the

human leukocyte antigen, HLA-Cw6. Conversely, type 2

does not show a family history, pres

ents after age 40, and is not associated with HLA-Cw6.[55] Type 1 accounts for about 75% of persons with p

soriasis.[56]

The classification o

f psoriasis as an autoimmune disease has sparked considera

ble debate. Researchers have proposed differing descrip

tions of psoriasis and psoriatic arthritis; some auth

ors have classif

ied them as autoimmune diseases[17][31][5

7] while others have classified them as distinct from autoimmune

diseases and referred

to them as immune-mediated inflammatory diseases.[29][58][59]

>>37955725
Because he is a massive fucking faggot? It's weird though, a lot of people want him here but every ill-advised anon in this thread is telling him to get lost. Why are they such big meanie poopy heads?

>>37955822
I'm no homosexual. Not male either. What point are you trying to prove?

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Severity[edit]

Distrib

ution of severity
There is no c

onsensus about

how to classify th

e severity of psoriasis. Mild psoriasis has been defined as a percentage of body surface area (BSA)_10, a Psoriasis Area Severity Index (PASI) score _10,

and a de

rmatology life quality index (DLQI) score _10.[60]

Moderate to severe psoriasis was defined by the same gro

up as BSA >10 or PASI score >10 and a DLQI sc

ore >10.[60] The D

LQI is a 10 question tool used to meas

ure the impact o

f several dermatologic diseases on daily functioning.

The

DLQI score ranges from 0 (minimal impairment) to 3

0 (maximal impairment) and is calculated with each answer being assigned 0-3 points with higher scores indicating greater social or occupational impairment.[61]

The psoriasis area severity index (PASI) is the most widely used measurement tool for psoriasis. PASI assesses the severity of lesions and the area affected and combines these two factors into a single score from 0 (no disease) to 72 (maximal disease).[62] Nevertheless, the PASI can be too unwieldy to use outside of research settings, which has led to attempts to simplify the index for clinical use.[63]

Management[edit]

>>37955732
Umm no. Why would you even ask that? That's so weird.

>>37954917
Tfw no good on model connie porn

>>37956315
I didn't need to know of this. Really didn't.

>>37956284
asking never hurts

>>37957251
Well, I guess you're right on that.