So what would the most chaotic way for her to go out be?
Secures the nomination but dies of a stroke a few months before the election?
To win the popular vote by a substantial margin while losing the electoral college to an insecure cuckolded treasonweasel
Blackmail
Come out as a misgendered man and lose the second election as Mister Hilton Rodham-Aberdin and then get shot in the back of the head by the Saudis or the Chinese or whoever lost the most money on xer.