So my estrogen synapses have burned out and estrogen no longer

>>7456717
How the hell did that happen and how do I avoid it?

i don't think this is a real thing

Please tell me this isn't real. You're going to give me tranny koro.

I've heard of trannies developing an allergy to their anti androgen or estrogen medication. Don't know how common it is.

>>7456717
>estrogen synapses
So, you're lying?

Even if you're just using the wrong term, estrogen receptor insensitivity is something that's happened to like, 3 people in recorded history, the odds are slimmer than an anorexic.

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>>7456784
>estrogen synapses

https://en.wikipedia.org/wiki/Estrogen_receptor#Disease

>>7456717
i fried mine a while back...
i just got an orchi and live as a femboy now. it's honestly not THAT bad

>>7456717
https://en.wikipedia.org/wiki/Estrogen_insensitivity_syndrome

Look for armitage, he has the treatment you give to the black clinics of chiba city

>>7456717
How would you even determine this? Would your E be low and T high?

>>7456717
>>>7456717
>How would you even determine this? Would your E be low and T high?

E would be the same but the results would be like if you weren't on it. The receptor sites get fried

>>7457143
????

But how would you know for sure? Like how did your endo know?

>>7456862
Two cases ever recorded, wow. If I found out I had this, I would kill myself on the spot. <1% chance of being transgender and <0.000001% chance of not being able to process estrogen in any way? You'd have to take that as a message from the universe that you were a mistake.

>>7456717
That's the sign that you're not trutrans.

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>>7456717
Your welcome.

>>7457163
>tfw androgen insensitivity syndrome is much more likely
>tfw I didn't get it
gonna run out of reasons to not kms pretty soon here

>>7457460
Being born female is 50%

>>7457163
Apparently there's a sizable portion of ftm's with partial or even complete androgen insensitivity syndrome.

And have you seen some of the trannies around here or elsewhere? I'd say like 50% are insensitive to estrogen based on how little it does for so many.
>>7457460
Right?
>>7457635
Shut up! It sucks that I got fucked and ended up a tranny when the chance was like .1%, the fact that I was basically a coinflip away from being born female fucks me up.

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>craziest science fiction ideas: #72,206

>>7458186
>>7457460
I would still kill myself but I would take it as somewhat less of a universal mandate.

>>7456717
could be rather that your AAs arent working, there are cases of people who develop tolerance to cypro for example

>>7456717
Are you sure you aren't taking something that binds tightly to the ER receptor, but doesn't enable it? Some drugs are SERMs (Selective Estrogen Receptor Modulators).

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>estrogen synapses
>synapses

>>7457143
>The receptor sites get fried
receptor proteins undergo constant turnover. the only way to lose the activity of a receptor is a mutation in the receptor or downstream proteins, which would require a mutation in all stem cell niches in your body which is so staggeringly unlikely to happen without also causing horrible death that it legitimately makes me want to laugh, or to have your immune system start picking up the hormone as foreign which is also unlikely.

>>7458840
Actually if the methylation process in the cell fails due to lack of the right molecules, you could stop making replacement estrogen receptors.

>>7460576
If your protein methylases are broken them you have FAR bigger problems than nonfunctional estrogen receptors.

>>7457057
Sick reference

With two reported cases your chances of having EIS are pretty slim. Also, it's not something that just happens one day, the receptors don't work from birth, so you might as well stop panicking and consult a good endo.

>>7457163
>You'd have to take that as a message from the universe that you were a mistake.
>being so thick you don't get the message from the first part

>>7460652
Not true, I fell and broke my protein methylases once and I was back up and fucking sluts in two weeks, no biggie
>tfw this is the level of science ITT

>>7460900
this >>7460576

>>7460652
Yep...