The other I was reading about Charles the V and what stroke me

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The other I was reading about Charles the V and what stroke me was how lucky he was to gain the Spanish throne as he was the 4th person in the succesion line. I was wondering how much would have Europe changed if either Juan or Miguel would have survived.
If Juan survived:
>Spain would have kept its alliance with the Habsburgs for the Italian wars
>Francis claim to the HRE would become stronger as Charles wouldn't have the financial muscle that he had in the other timeline
>In either case Francis wouldn't have been so agressive towards Spain and the Habsburghs are they wouldn't be a single force.
>In any case protestantism wouldn't have spreaded that much as Francis would be the emperor or wouldn't ally himself with the protestant kings as there was no need
>France may be able to keep Milan/Lombardy in this timeline.
>Spain wouldn't have been involved in as many wars and would mostly focus on colonization,building and army and fighting the Ottomans.
>Assuming that Juan would follow Ferdinand's policies Spain may would have been able to grow a strong manufacturing sector as they wouldn't own Flanders and grow a bigger navy.
>This may have ended in Spain hitting the industrial revolution a in a couple of centuries.
>England colonial ambitions would move straigth to India as Spain's navy was too big for them to compete in America.
>France would expand through the HRE as the Spanish and Habsburgh aliance would be weaker each generation and the fact that Charles would have fewer resources to fight the Ottomans
If Miguel survived
>Something similar to Juan's timeline would happen + the union with Portugal
>This would mean that Miguel may have grown an interest in India due him having the right to colonize it due Tordesillas + the increase of resources as he now owns Castille as well.
Is my alternate history feasable or am I missing something?