Can anyone suggest a serious anime with strong themes of making something out of life.
Like welcome to the nhk except more feels.
Or something thats super powerful and sad, feeling depressed desu senpai
Aoi no Bungaku
Serial Experiments Lain
This is a random sampling of good shit in your categories, I'm sure something here will interest you in particular.
but anon, almost none of those are 2deep4u or artsy, just feelsy.
the artsy chart has none of these on it too, but the worthwhile one has quite a few of them so i'll post that despite it not really meeting OP's rec
Charlotte was a massive disappointment for me, I wouldn't recommend it. It also doesn't relate to OPs request that much
Angel beats does relate to making something out of life, though in a different way
The last two episodes of Neon Genesis Evangelion, and NOT the End of Evangelion movie.
I recommend watching both episodes, and the movie, and then watching this video https://www.youtube.com/watch?v=NAMAwErYRpQ if you have any followup questions on what that all meant.