Retarded? OP, you are retarded. All of life is a war, survival of the fittest, from the smallest micro -organism to largest mammals. Every single second your body is at war with virii, bacteria and ITSELF in a battle to survive evolution and mutation.
Your immune system is the most sophisticated war machine known.
>>7779028 here Like to add, i only just read your post re autoimmune diseases. That sucks. But my comment above still stands firm, evolution is a constant bio-chemical battle... sorry for your illness man.
>>7779054 Basically the immune system has to be taught not to trigger a response when it detects proteins on the surface of harmless substances, including self cells, meaning that normally immune cells which are self-reactive are destroyed or inactivated. Autoimmunity is obviously a breakdown of this system and the cause/reason behind it varies depending on the condition and this is something I'm still learning myself.
>>7779002 that's not how evolution works... random changes happen and only those conducive to a healthy species in a given climate survive. ideally that is (ideal in terms of the function of evolution, not ideal in terms of desirable to humans). currently, many people and animals have biologically undesirable traits, but are kept alive to satisfy human desires.
>>7778993 >Why is the immune system so unbelievably retarded?
The most complex system in your body that requires countless cells to suicide in order not to create an auto-immunological problem, with a separate system that allows storage of antibody information within separate group of cells.
>>7779002 Blame modern healthcare that saves every person with minor and major health problems and allows them to procreate. I'm not advocating eugenics, just stating the fact. We halted evolution of our species, and without introducing splicing we will face consequences pretty soon.
No it does not. Autoimmune diseases happen often when the pathogen has a similar protein structure to your own cells. (That's why some cases of diabetus are caused by viruses - the similar structure starts a cascade of faulty cells attacking its own cells). It's all chemical gradients and proteins that work in a simple key-keyhole manner. No real "intelligence" behind this system. No decision making.
>>7779104 >3. Those signals would obviously be used by viruses and bacteria to prevent an immune response, thus killing us.
Also incorrect. This does happen, immuno mimicry is nothing new, just look at common parasites.
>>7779120 It's evolution because there is an increased amount of people with sickle cell in areas where malaria is more common. It provides an selective advantage. Same as other mutations like non-expression of Duffy protein.
Immunity can be broken up into two parts, innate and adaptive immunity. Innate immunity consists of a variety of general responses that have evolved over millions of years to differentiate between microbial and self components. It's the initial response during an infection and does not adapt to different pathogens. Examples include complement system, Toll-like receptors, and innate cell types (neutrophils, NK cells...)
Adaptive immunity is primarily coordinated by B and T cells and takes time (days-weeks) to mount a pathogen-specific attack. It's important to note that B and T cells evolve new receptors on a daily basis and go through a series of checkpoints to determine if that cell reacts too strongly to self peptides. If a self reactive cell gets through then there are ways to render it harmless (anergy or suppression by T cells).
Autoimmune diseases occur when some part of self tolerance breaks down and the adaptive response is directed towards normal healthy components of the body. Three ways this can happen are 1. antibodies directed against cell surface components 2. immune complexes deposited in tissue 3. effector T cells
I mentioned a series of checkpoints earlier that B and T cells go through during their maturation phases. This screens new cells for auto reactivity. Even when functioning properly some self reactive cells move into the peripheral. If left unchecked they can trigger an adaptive response against healthy cells.
Both environmental and genetic factors contribute to autoimmunity. It's important to realize that the immune system is not perfect.
It also often makes you suffocate if you are a homozygote, not much of an advantage here. It gives you a 50% chance of your offspring being immune to malaria and 25% chance of it dying. Pretty faulty evolutionary mechanism if you ask me, but I guess it's evolution nonetheless.
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