You have 10 seconds to name a protagonist with an imouto who openly loathes him. Not Tsundere. Actually does hate him.
You'll have a hard enough time listing imoutos who don't outright tear their clothes off and beg their brothers to fuck them, target audience being what it is.
An imouto in anime is a cute brainless fucktoy whose purpose in life is to wander into MC's room, dispense blowjobs, and say random words that incorporate 'nii'. That's literally it.
I've been on 4chan since 2005 and this is as close as you're getting.
I wouldn't say actively loathed, but Chuunibyou had Kuzuha, who genuinely thought her older brother Yuuta was a cringe-tier autist and did not secretly want his dick.
Clarissa from that depressing comic probably hates everyone in her family, but isn't manga nor anime.
Other than that the closest I can think of is that mango with the neet (kazuya, i think) who goes back to his elementary school days and starts raping lolis. His rape daughter really hated him.
The only time I've ever seen that is in lolidom where the imouto only sees her oniichan as a pathetic, albeit convenient, living dildo.
It's like having a harem where all the girls actively dislike the OP and he doesn't win a single one - it's just not going to be made outside of a joke or for some "serious" show which panders to the contrarian.
They had a brief falling out where they hated eachother, sort of, maybe.
Couldn't you have said little brother? Would have been so much easier.
I was going to choose pic related, but that works better.
well she hate her brother because he cuck all the kindred and hogging the founder father by himself?