I'm panicking about this right now and would like any reassurance or advice. I looked over my latest blood test and these were the results. Is there anything I should be concerned about here? My testosterone looks way, way too high.
according to http://www.bumc.bu.edu/endo/clinics/transgender-medicine/guidelines/ it should be 30 – 100 ng/dl but I don't know anything about biology
I'm having a panic attack right now over this because I don't want any more masculinization to happen to my body
Hormones exist in pairs with a series of negative feedback loops keeping their relative levels in check. One of those loops is to increase the opposite hormone production when there's an imbalance.
Really you just need to cut your balls off.
I started hormones prior to puberty so that's not really something I need to worry about -- unless 188 is something I should be concerned with? Any input would be very much appreciated
I already emailed her and I'll call tomorrow but it's 2am here
how does this translate to physiological effects? I just don't want to suddenly start growing a beard or talk an octave lower
I'm not an endocrinologist so I can't tell you specifically what you can expect physiologically, but you should simply view it as building a resistance to E.
Well, "resistance" isn't the right word, but you can think of it that way.
Whenever you introduce hormones into your body, 3 things happen.
1: Cells dedicated to the production of that hormone stop dividing.
2: Cells dedicated to the production of the opposite hormone multiple at a higher rate
3: Cell receptors for (in this case estrogen) on the membranes of cells making up the rest of your body cease to form form for estrogen.
So while it's not "resistance" per se, it can be effectively viewed as such in regards to administering dosages for yourself.
I'm 27 and have been on the medication legally and monitored for over a decade and my T level has never been this high. Is it something I need to be concerned about is the most relevant question I guess?
You're trying to fight homeostasis.
I wasn't entirely kidding when I told you to cut your balls off though. It's a problem that will only get worse, or more expensive as the cocktail of drugs you'll need to take will get more and more complex
What are you taking?
All your values are high. A bit too high estrogen, a bit too high SHBG, and way too high tesosterone.
If you take spiro, then take more spiro, if you're taking cypro, take more cypro.
If you're taking bicalutamide, then there's no problem, because it doesn't prevent you from creating tesosterone.
estradiol 2mg x 2
finasteride 5mg x 1
spironolactone 50mg x 2
I'll talk to my doctor tomorrow I think I just need to switch to spiro 50 x 3 or spiro 100 x 2. Not even sure what the point of finasteride is
The amount of bad biology in this thread is astounding...
If you are taking anti-androgen (spiro, cypro) at appropriate dose (150-200 mg), you will *not* get masculinizing effect, regardless of T level. T blood level is not linked to T cellular effects when taking an anti-androgen. (That's the idea between any competitive antagonist - it binds to he androgen receptor but does not cause the effects. Administered at sufficiently "high" dose, all the receptors are filled by it rather than T)
In a vacuum T levels don't need to be reduced as long as you are taking an appropriate dose of antiandrogen, in regards to masculinizing effects. (There are side benefits to get it low however, reducing the doses of the meds, easier on the liver, ...)
T levels will get lower with time as the intersticial tissue of the testis degenerates. Or if you cut your balls. Or if you are taking an antigonadotrope such as lupron, or cypro (which is also an antiandrogen - hence the confusion). Spiro is weaker than these for antigonadotrophic effect. But that's not really a problem as we've seen.
So maybe have your spiro level upped a bit (it's basically safe to go 200 even if not strictly necessary - check with physician if it would be ok with you). And don't worry too much about the T level, there are daily variation in your body, but also uncertainty due to the lab apparatus/method...
digits and knowledge checked. thank you for your advice - gonna bump it up w/ her supervision
I am totally oblivious when it comes to the science of hormones and all of that so I really appreciated your post. I've been on spiro for 10+ years and this is the highest I've ever seen T level, hence my concern and confusion. Hard to find info on this subject without hitting a tumblr wall of feelings. So thanks again